李艳琴    

性别：女    
职称：副教授        
通讯地址：betway必威，湖北省武汉市武昌区东湖路185号（邮编：430071）

学习经历：

2008 – 2009        博士后   药理学   美国匹兹堡大学医学院药理系
2005 – 2008        博士    药理学   北京大学                                    
2003 – 2004        联合培养研究生   北京301医院/第二炮兵总医院
2002 – 2005        硕士  病理生理学 必威betway中文版        
1997 – 2002        学士  临床医学  必威betway中文版

工作经历：

2010 – 至今   副教授   药理学   betway必威

研究领域：

神经精神药理，新药临床前评价

研究兴趣与方向：

1、药物滥用和成瘾  阿片类物质及其他神经活性物质（可卡因类、大麻类、酒精、尼古丁等）成瘾的神经药理机制及药物作用靶标新发现，动物模型及治疗新药研发；
2、神经精神疾病药物研究  主要包括精神分裂症和抑郁症的神经病理机制及新药作用机制研究；
3、代谢性疾病神经机制及药物研究  主要包括肥胖、糖尿病等中枢神经内分泌病理调节机制及疾病预防药物的研究；
4、新药临床前评价 包括治疗神经精神系统疾病、肿瘤、心血管疾病、消化系统疾病等药物的临床前药理及药效评价。

承担课题：

1、国家自然科学基金青年基金项目：81000574， 2011.1-2013.12。
2、中央高校专项研究基金： 4103004， 2011.1-2012.12。
3、必威betway中文版人才引进启动基金项目：306271203，2011.1-2013.12。

教学情况：

本科生：药理学、实验药理学
研究生：分子药理学

社会兼职：

中国药理学会会员，The International Journal of Neuropsychopharmacology特约审稿人。

授权专利：

1、陆林，时杰，李艳琴，张肖丽，朱薇莉，史海水。雷帕霉素在制备治疗吗啡类药物成瘾的药物上的用途。专利号：CN.101444506A。

代表性论文：

发表文章

1、Li YQ, Xue YX, He YY, Li FQ, Xue LF, Xu CM, Sacktor TC, Shaham Y, Lu L. Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memory. J Neurosci. 2011 Apr 6;31(14):5436-46.
2、Li YQ, Li FQ, Wang XY, Wu P, Zhao M, Xu CM, Shaham Y, Lu L. Central amygdala ERK signaling pathway is critical to incubation of opiate craving. J Neurosci. 2008 Dec 3;28(49):13248-57.
3、Li YQ, Wang XY, Zhai HF, Zheng YQ, Zhang XY, Kosten T, Lu L.. Effects of early postnatal sibling deprivation on anxiety and vulnerability to cocaine in offspring rats. Psychopharmacology (Berl). 2008 Aug;199(2):245-53.
4、Li YQ, Wang XY, Zhai HF, Zhang XY, Kosten T, Lu L. Sex- and age-dependent effects of early postnatal sibling deprivation on spatial learning and memory in adult rats. Behav Brain Res. 2008 Jan 10;186(1):138-42.
5、Zhai H, Li YQ (co-first author), Wang X, Lu L.. Drug-induced alterations in extracellular signal-regulated kinase (ERK) signalling pathway: implications for reinforcement and reinstatement (review). Cell Mol Neurobiol. 2008 Feb;28(2):157-72.
6、Fang Q, Li FQ, Li YQ, Xue YX, He YY, Liu JF, Lu L, Wang JS. Cannabinoid CB(1) receptor antagonist rimonabant disrupts nicotine reward-associated memory in rats. Pharmacol Biochem Behav. 2011 Oct;99(4):738-42. Epub 2011 Jun 23.
7、Li FQ, Xue YX, Wang JS, Fang Q, Li YQ, Zhu WL, He YY, Liu JF, Xue LF, Shaham Y, Lu L. Basolateral amygdala Cdk5/p35 activity mediates cocaine rewarding memory. J Neurosci, 2010 Aug 4;30(31):10351-9.
8、Yu LL, Wang XY, Zhao M, Liu Y, Li YQ, Li FQ, Wang X, Xue YX, Lu L. Effects of cannabinoid CB1 receptor antagonist rimonabant in consolidation and reconsolidation of methamphetamine reward memory in mice. Psychopharmacology (Berl). 2009 Jun;204(2):203-11.
9、Wang XY, Zhao M, Ghitza UE, Li YQ, Lu L. Stress impairs reconsolidation of drug memory via glucocorticoid receptors in the basolateral amygdale. J Neurosci. 2008 May 21;28(21):5602-10.
10、Liu J, Li YQ , Ouyang JP et al. Protective effects of NADH on cardiac fibroblasts apoptosis induced by hydrazine. Med J Chin PLA. (2008) 33: 305-307.
11、Li YQ , Liu J, Ouyang JP , et al. The mechanism of the apoptosis of cardiac fibroblast induced by hydrazine. Chin J Aerospace Med, (2006)17: 176-179.
12、Li YQ , Liu J, Ouyang JP , et al. Effect of hydrazine on Proliferation and apoptosis of cardiac fibroblast. Medical Journal of Wuhan University. (2005)26: 326-328.

会议报告

1、The Fourth China-France Biotherapy and Regenerative Medicine International Symposium ，China，Wuhan，June 18-19, 2011.Yanqin Li, Yan-Xue Xue, Yin-Yin He, Fang-Qiong Li, Lif-Fen Xue, Chun-Mei Xu, Todd Charlton Sacktor, Yavin Shaham, Lin Lu。Infusion ZIP into nucleus accumbens core abolishes long-term drug reward memory。(Oral report)
2、Annual Meeting for the Society of Neuroscience, Chicago, USA. Oct. 17-21, 2009.  Yanqin Li, Yanxue Xue, Fang-qiong Li, Yavin Shaham and Lin Lu. Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memory. (Poster)
3、CSPN (The Chinese Society of Psycho-Neuroscience) 2008 Conference, Changchun, China. Aug. 1-6, 2008. Yanqin Li , Fang-qiong Li, Yanxue Xue, Lin Lu. Basolateral Amygdala CDK5 is critical to the associated rewarding learning and memory. (Oral report)
4、The 6th Meeting of the Society for Drug Dependence, Xian, China. Nov. 22-25, 2008. Yanqin Li , Fangqiong Li, Xiaoyi Wang, Ping Wu, Mei Zhao, Chun-mei Xu, Yavin Shaham and Lin Lu. Central amygdala ERK signaling pathway is critical to incubation of opiate craving. (Oral report)
5、The 6th Meeting of the Society for Drug Dependence, Xian, China. Nov. 22-25, 2008.  Yanqin Li, Fangqiong Li, Yanxue Xue, Lulu Yu, Yavin Shaham and Lin Lu. Role of mTOR signaling pathway in opioid drug reward and seeking. (Oral report)

会议摘要

6、CSP (Chinese Society for Pharmacology) 2007 Conference, Wuhan, China. Nov 6-9, 2007. Yanqin Li , Fang-qiong Li, Ping Wu, Lin Lu. Translational control via the mammalian target of rapamycin pathway is critical for drug reward and seeking.
7、CSP (Chinese Society for Pharmacology) 2007 Conference, Wuhan, China. Nov 6-9, 2007. Yanqin Li, Fangqiong Li, Ping Wu, Lin Lu. Role of ERKsignaling pathway in incubation of morphine after withdrawal.
8、CSDD (Chinese Society for drug dependence) 2006 Conference, Hainan, China. Nov 3-5, 2006. Yanqin Li, Xiao-Yi Wang, Haifeng Zhai, Lin Lu. Effects of early postnatal sibling deprivation on anxiety and vulnerability to cocaine in offspring rats.