段炼

性别：男

职务/职称:特聘副研究员

通讯地址（含邮编）：betway必威（医学部8号楼903） 

学习简历：

2006-2011      中科院上海有机化学研究所，获有机化学博士学位

2002-2006      必威betway中文版化学系，获学士学位

工作简历：

2018 至今       必威betway中文版，副研究员

2012-2017      美国布朗大学，博士后研究员              

2011-2012      中科院上海有机化学研究所，助理研究员

社会兼职:

业绩概要:

以天然药物分子生物合成为出发点，从事生物合成、酶学功能和蛋白质结构的研究，在博士和博士后期间在具有国际影响力的期刊上发表了多篇文章。

获奖情况：

研究领域:

酶学机制、结构生物学、天然药物生物合成

研究兴趣与方向:

结构生物学与药物生物合成研究的结合交叉：利用结构生物学的方法阐明蛋白结构及其与小分子底物相互作用关系，从而达到解析天然药物分子生物合成过程中关键蛋白的特殊酶学机制的目的。并在此基础之上，通过对蛋白结构的定向改造来拓展和提高酶的催化功能，为天然药物生物合成途径的改造和新型天然产物的发现提供基础。

承担课题与经费：

2018 必威betway中文版人才计划/引进人才科研启动经费 100万

教学情况：

研究组成员:

国际国内学术报告:

科研成果（至少应有近五年的代表性成果）:

1.Lian Duan, Gerwald Jogl and David E. Cane. The Cytochrome P450-Catalyzed Oxidative Rearrangement in the Final Step of Pentalenolactone Biosynthesis: Substrate Structure Determines Mechanism. J. Am. Chem. Soc., 2016, 138, 12678−12689.

2.Lian Duan, Shoufeng Wang, Rijing Liao and Wen Liu. Insights into Quinaldic Acid Moiety Formation in Thiostrepton Biosynthesis Facilitating Fluorinated Thiopeptide Generation. Chem. Biol., 2012, 19, 443-448.

3.R. Liao, L. Duan, C. Lei, H. Pan, Y. Ding, Q. Zhang, D. Chen, B. Shen, Y. Yu and W. Liu. Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications. Chem. Biol., 2009, 16, 141–147. (Co-first Author).

4.Yi Yu, Lian Duan, Qi Zhang, Rijing Liao, Ying Ding; Haixue Pan, Evelyn Wendt-Pienkowski, Gongli Tang, Ben Shen and Wen Liu. Nosiheptide Biosynthesis Featuring a Unique Indole Side Ring Formation on the Characteristic Thiopeptide Framework. ACS Chemical Biology, 2009, 4(10), 855-864.

5.Patrick N. Blank, Golda G. Harris, Wayne K. W. Chou, Lian Duan, David E. Cane, and David W. Christianson. Substitution of Aromatic Residues with Polar Residues in the Active Site Pocket of epi-Isozizaene Synthase Leads to the Generation of New Cyclic Sesquiterpenes. Biochemistry, Just Accepted Manuscript.

6.Travis A. Pemberton, Mengbin Chen, Golda G. Harris, Wayne K. W. Chou, Lian Duan, Mustafa Köksal, Alex S. Genshaft, David E. Cane, and David W. Christianson. Exploring the Influence of Domain Architecture on the Catalytic Function of Diterpene Synthases. Biochemistry, 2017, 56 (14), pp 2010–2023.

7.Yi Yu, Heng Guo, Qi Zhang, Lian Duan, Ying Ding, Rijing Liao, Chun Lei, Ben Shen and Wen Liu. NosA Catalyzing Carboxyl-Terminal Amide Formation in Nosiheptide Maturation via an Enamine Dealkylation on the Serine-Extended Precursor Peptide. J. Am. Chem. Soc., 2010, 132, 16324–16326.

8.Qi Zhang, Yuxue Li, Dandan Chen, Yi Yu, Lian Duan, Ben Shen & Wen Liu. Radical-mediated enzymatic carbon chain fragmentation-recombination. Nature Chemical Biology, 2011, 7, 154–160.

9.Jing Li, Xudong Qu, Xinyi He, Lian Duan, Guojun Wu, Dexi Bi, Zixin Deng, Wen Liu, Hong-Yu Ou. ThioFinder: A Web-Based Tool for the Identification of Thiopeptide Gene Clusters in DNA Sequences. Plos One 2012, 7, e45878.

10.Kai Zhang, Zhao Chen, Chuluo Yang, Xiaowei Zhang, Youtian Tao, Lian Duan, Liang Chen, Linna Zhu, Jingui Qin and Yong Cao. Improving the performance of phosphorescent polymer light-emitting diodes using morphology-stable carbazole-based iridium complexes. J. Mater. Chem., 2007, 17, 3451-3460.

11.发明专利：一种短链脱氢酶TsrU的功能及其应用。发明人：刘文， 段炼， 王守锋， 廖日晶。专利号：ZL 2012 1 0010297.0 。