卞光凯

性别：男

职务/职称: 特聘副研究员

通讯地址（含邮编）：必威betway中文版医学部8号楼9楼903，430075

学习简历：

2012-2017      必威betway中文版，betway必威，生物化学与分子生物学，博士

2009-2012      江苏师范大学，生命科学学院，植物学，硕士

2005-2009      徐州师范大学，生命科学学院，生物技术，学士

工作简历：

2017-2019      betway必威，博士后

2020-至今   betway必威，特聘副研究员

业绩概要:

开发基于微生物高产平台的天然产物挖掘新策略，挖掘并阐明了一系列倍半萜、二萜、二倍半萜新骨架化合物生物合成机理，在国内外学术期刊，如Nature Communications、Journal of the American Chemical Society、Angewandte Chemie International Edition、Metabolic engineering、Organic letters等期刊上发表多篇研究论文。

研究领域:

萜类天然产物生物合成

研究兴趣与方向:

萜类天然产物生物合成

颠覆传统天然产物挖掘方式，将合成生物学和代谢工程的应用范围拓展到天然产物研究领域。以生物信息学分析、大肠杆菌以及酿酒酵母萜类高效底盘以及酶的精确改造为基础，推动萜类骨架及其生物合成元件的挖掘及组合应用，挖掘并鉴定具有生物活性及新（骨架）萜类化合物及其衍生物，阐明其生物合成及环化机理。

科研成果:

(1)He H#, Bian G#, Herbst-Gervasoni, C. J., Mori, T., Shinsky, S. A., Hou, A., ... & Christianson, D. W. (2020). Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases. Nature Communications, 11(1), 1-13.

(2)Siemon T#, Wang Z#, Bian G#, Seitz T, Ye Z, Lu Y, Cheng S, Ding Y, Huang Y, Deng Z, Liu T, Christmann M. (2020). Semisynthesis of plant-derived englerin A enabled by microbe engineering of guaia-6, 10 (14)-diene as building block. Journal of the American Chemical Society, 142(6), 2760-2765.

(3)Bian G#, Rinkel J#, Wang Z#, Lauterbach L, Hou A, Yuan Y, Deng Z, Liu T, Dickschat JS. (2018). A clade II‐D fungal chimeric diterpene synthase from Colletotrichum gloeosporioides produces dolasta‐1 (15), 8‐diene. Angewandte Chemie International Edition, 57(48), 15887-15890.

(4)Bian G#, Hou A#, Yuan Y, Hu B, Cheng S, Ye Z, Di Y, Deng Z, Liu T. (2018). Metabolic engineering-based rapid characterization of a sesquiterpene cyclase and the skeletons of fusariumdiene and fusagramineol from Fusarium graminearum. Organic letters, 20(6), 1626-1629.

(5)Bian G, Ma T, & Liu T. (2018). In vivo platforms for terpenoid overproduction and the generation of chemical diversity. Methods in Enzymology, 608, 97-129.

(6)Bian G, Deng Z, Liu T. (2017). Strategies for terpenoid overproduction and new terpenoid discovery. Current opinion in biotechnology, 48, 234-241.

(7)Bian G#, Han Y#, Hou A, Yuan Y, Liu X, Deng Z, Liu T. (2017). Releasing the potential power of terpene synthases by a robust precursor supply platform. Metabolic engineering, 42, 1-8.

(8)Bian G, Yuan Y, Tao H, Shi X, Zhong X, Han Y, Fu S, Fang C, Deng Z, Liu T. (2017). Production of taxadiene by engineering of mevalonate pathway in Escherichia coli and endophytic fungus Alternaria alternata TPF6. Biotechnology journal, 12(4), 1600697.