虞沂

性别：男

职务/职称：教授、博导、珞珈青年学者

通讯地址：

湖北省武汉市武昌区东湖路185号betway必威，430071

学习简历：

1996.9 – 2002.6   华中农业大学生物技术基地班，本硕连读
2003.9 – 2007.6  中科院微生物研究所，博士

工作简历：

2007.7 – 2009.6  上海交通大学生命科学技术学院生物工程系，讲师

2007.3 – 2009.6  上海有机化学研究所，合作研究
2009.7 – 2010.6  华中农业大学生命科学技术学院，讲师
2012.8 – 2013.8  美国Washington University in Saint Louis, 访问学者

2010.7 至今     betway必威，教授、博导

2018.1 – 2018.12  英国牛津大学，高级访问学者

获奖情况：

教育部2007年度高等学校科学技术奖自然科学奖二等奖

2015-2016年度必威betway中文版医学部突出贡献奖

2016-2017 年度必威betway中文版医学部朱裕璧奖

2016年度必威betway中文版十佳教师（第十届）

2018年第八届湖北省高等学校教学成果奖三等奖

2019年世界大学生药苑论坛优秀壁报奖、优秀论文奖，以及创新成果一等奖

2020年度必威betway中文版本科教学业绩奖

研究领域:

药用植物天然产物的化学生物学与合成生物学

研究兴趣与方向:

以中草药和微生物来源天然产物为基础，研制和开发新药一直是国际化学界和医药界共同关注的重点领域。天然产物的生物合成是以小分子的简单化合物作为底物，经过一系列顺序催化反应，最终形成复杂化学结构的过程。本人的研究兴趣在于通过代谢工程和组合生物合成研究植物和微生物来源的复杂天然产物的生物合成，即利用基因工程技术，有目的地对细胞代谢途径进行精确的修饰或改造，以提高目的天然产物活性或产量、或合成新的代谢产物；或是通过操纵天然产物生物合成途径中的基因来产生非天然的天然产物类似物库，并从中发现和发展更具应用价值的药物。

承担课题与经费：

2010年度武汉市青年科技晨光计划
2010年度教育部新教师基金

2011年国家自然科学基金青年项目

2011年973子课题

2014年973子课题
2015年国家自然科学基金面上项目

2017年必威betway中文版自主科研-拔尖创新人才

2018年国家自然科学基金中英合作交流项目

2018年国家自然科学基金面上项目

2019年国家重点研发计划合成生物学重点专项子课题

教学情况：

本科生课程：免疫学，化学生物学

研究组成员:

博士后1名，博士研究生4名，硕士研究生12名

学术兼职:

1．教育部高等学校中药学类专业教学指导委员会委员（2018.10-2022.10）

2．全国药用植物及植物药专业委员会委员（2018.1-2023.12）

3．湖北省药学会第十三届理事会中药天然药专业委员会常务委员（2020.11-2025.11）

4．《中草药》杂志第一届青年编辑委员会委员（2019.10-2021.10）

5．Frontiers in Chemistry and Molecular Biosciences副主编

科研成果:（*通讯作者）

1. Linrui Wu^#, Qian Zhang^#, Zixin Deng, Yi Yu*, From solo to duet, intersections of natural product assembly with self-resistance, Natural Product Reports, 2022, DOI: 10.1039/d1np00064

2. Shan Wang^#, William D G Brittain^#, Qian Zhang^#, Zhou Lu, Ming Him Tong, Kewen Wu, Kwaku Kyeremeh, Matthew Jenner, Yi Yu*, Steven L Cobb*, Hai Deng*, Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase, Nature Communications, 2022, 13(1):62

3. Qian Zhang^#, Hao-Tian Chi^#, Linrui Wu, Zixin Deng, Yi Yu*. Two Cryptic Self-Resistance Mechanisms in Streptomyces tenebrarius Reveal Insights into the Biosynthesis of Apramycin. Angew. Chem. Int. Ed. Engl., 2021, 60(16):8990-8996

4. Yating Liu^#, Linrui Wu^#, Zixin Deng, Yi Yu*. Two putative parallel pathways for naringenin biosynthesis in Epimedium wushanense. RSC Advances, 2021, 11, 13919 - 13927

5. Fleurdeliz Maglangit*, Yi Yu*, Hai Deng*. Bacterial pathogens: threat or treat (a review on bioactive natural products from bacterial pathogens). Natural Product Reports, 2021, 38(4):782-821

6. Haigang Song, Cong Rao, Zixin Deng, Yi Yu*, James Naismith*. The biosynthetic pathway of the benzoxazole in nataxazole proceeds via an unstable ester and has synthetic utility. Angew. Chem. Int. Ed. 2020, 59, 2–11

7. Lie Ma^#, Siyao Sun^#, Ziyu Yuan, Zixin Deng, Yi Yu*. Three putative DNA replication/repair elements encoding genes confer self-resistance to distamycin in Streptomyces netropsis. Acta Biochimica et Biophysica Sinica. 2019,10.1093/abbs/gmz133

8. Yating Liu^#, Li Su^#, Qing Fang, Jioji Tabudravu, Xiaohui Yang, Kirstie Rickaby, Laurent Trembleau, Kwaku Kyeremeh, Zixin Deng, Hai Deng*, Yi Yu*. Enzymatic reconstitution and biosynthetic investigation of the bacterial carbazole neocarazostatin A. Journal of Organic Chemistry, 2019, 84, 24, 16323-16328

9. Yingying Chang, Baozhong Chai, Yunkun Ding, Min He, Linghui Zheng, Yun Teng, Zixin Deng, Yi Yu*, Tiangang Liu*. Overproduction of gentamicin B in industrial strain Micromonospora echinospora CCTCC M 2018898 by cloning of the missing genes genR and genS. Metabolic Engineering Communications, 2019, 9, e00096

10. Yun X, Zhang Q, Lv M, Deng H, Deng Z, Yu Y.* In vitro reconstitution of the biosynthetic pathway of 3-hydroxypicolinic acid. Organic & Biomolecular Chemistry, 2019, 17(3):454-460

11. Ding W., Ji W., Wu Y., Wu R., Liu W., Ma X., Zhang W., Xu P., Deng Z., Tang B., Yu Y.*, Zhang Q*. Biosynthesis of the nosiheptide indole side ring centers on a cryptic carrier protein NosJ. Nature Communications, 2017, 8(1):437. DOI: 10.1038/s41467-017-00439-1

12. Yu Y., Zhang Q., Deng Z., Parallel pathways in the biosynthesis of aminoglycoside antibiotics. F1000Res. 2017, doi: 10.12688/ f1000research.11104.1

13. Su Li, Zhang R, Kyeremeh K, Deng Z, Deng H* and Yu Y*. Dissection of the neocarazostatin A C4 alkyl side chain biosynthesis by in vitro reconstitution. Organic & Biomolecular Chemistry, 2017, 15(18): 3843-3848

14. Ding W, Li Y, Zhao J, Ji X, Mo T, Qianzhu H, Tu T, Deng Z, Yu Y, Chen F, Zhang Q*. The Catalytic Mechanism of the Class C Radical S-Adenosylmethionine Methyltransferase NosN. Angew Chem Int Ed Engl., 2017, 56(14):3857-3861

15. Ding W, Wu Y, Ji X, Qianzhu H, Chen F, Deng Z, Yu Y, Zhang Q*. Nucleoside-linked shunt products in the reaction catalyzed by the class C radical S-adenosylmethionine methyltransferase NosN. Chem Commun (Camb)., 2017, 53(37):5235-5238

16. Su Li, Lv Meinan, Kyeremeh Kwaku, Deng Zixin, Deng Hai and Yu Yi *. A ThDP-dependent enzymatic carboligation reaction involved in Neocarazostatin A tricyclic carbazole formation. Organic & Biomolecular Chemistry, 2016, 14(37): 8679-8684

17. Lv M, Ji X, Zhao J, Li Y, Zhang C, Su L, Ding W, Deng Z, Yu Yi* and Zhang Q*. Characterization of a C3 Deoxygenation Pathway Reveals a Key Branch Point in Aminoglycoside Biosynthesis. J AM CHEM SOC, 2016, 138(20):6427-35

18. Huang S., Elsayed S., Lv M., Tabudravu J., Rateb M., Gyampoh R., Kyeremyh K., Ebel R., Jaspars M., Deng Z., Yu Yi* and Deng H.* Biosynthesis of neocarazostatin A reveals the sequential carbazole prenylation and hydroxylation in the tailoring steps. Chemistry & Biology, 2015, 22(12):1633-42

19. Lv Meinan, Zhao Junfeng, Deng Zixin and Yu Yi*. Characterization of the biosynthetic gene cluster for benzoxazole antibiotics A33853 reveals unusual assembly logic. Chemistry & Biology, 2015, 22(10):1313-1324.

20. Huang S, Tabudravu J, Elsayed SS, Travert J, Peace D, Tong MH, Kyeremeh K, Kelly SM, Trembleau L, Ebel R, Jaspars M, Yu Yi* and Deng H*. Discovery of a Single Monooxygenase that Catalyzes Carbamate Formation and Ring Contraction in the Biosynthesis of the Legonmycins. Angew Chem Int Ed Engl. 2015, 54(43):12697-12701

21. Huang S, Tong MH, Qin Z, Deng Z, Deng H, Yu Y.*. Identification and characterization of the biosynthetic gene cluster of thiolutin, a tumor angiogenesis inhibitor, in Saccharothrix algeriensis NRRL B-24137. Anticancer Agents Med Chem, 2015, 15(3):277-84.

22. Liu G, Zhang M, Mo T, He L, Zhang W, Yu Y*, Zhang Q*, Ding W*. Metabolic flux analysis of the halophilic archaeon Haladaptatus paucihalophilus. Biochem Biophys Res Commun., 2015, 467(4):1058-62

23. Long Ma, Axel Bartholome, Ming Him Tong, Zhiwei Qin, Yi Yu, Thomas Shepherd, Kwaku Kyeremeh, Hai Deng* and David O'Hagan*. Identification of a fluorometabolite from Streptomyces sp. MA37: (2R3S4S)-5-fluoro-2,3,4-tri-hydroxypentanoic acid. Chemical Science, 2015, 6(2):1414-1419

24. Hao C.L., Huang S., Deng Z.X., Zhao C.M., Yu Y.* Mining of the pyrrolamide antibiotics analogs in Streptomyces netropsis reveals the amidohydrolase-dependent "iterative strategy" underlying the pyrrole polymerization. PLOS ONE, 2014, 9(6):e99077.

25. Qin Zhiwei, Wang Xiaoling, Rateb Mostafa, Ass'ad Lina, Jaspars Marcel, Deng Zixin, Yu Yi, Deng Hai*. Disruption of a Methyltransferase Gene in Actinomycin G Gene Cluster in Streptomyces iakyrus Increases the Production of Phenazinomycin. FEMS Microbiology Letters, 2014, 352(1): 62-8

26. Sheng Huang, Long Ma, Ming Him Tong, Yi Yu*, David O'Hagan and Hai Deng* Fluoroacetate biosynthesis from the marine-derived bacterium Streptomyces xinghaiensis NRRL B-24674. Org Biomol Chem, 2014, 12(27): 4828-4831

27. Varman, A.M. ^#, Yu, Y. ^#, You L., Tang, Y.J. Photoautotrophic production of D-lactate in an engineered cyanobacterium. Microbial Cell Factories, 2013, 12: 117 (^#Contributed equally)

28. Qin, Z., Huang, S., Yu, Y.*, Deng, H*. Dithiolopyrrolone natural products: isolation, synthesis and biosynthesis. Marine Drugs, 2013, 11(10):3970-97

29. Yu, Y., You, L., Liu, D.Y., Hollinshead, W., Tang, Y.J., Zhang, F.Z. Development of Synechocystis sp. PCC 6803 as a Phototrophic Cell Factory. Marine Drugs, 2013, 11(8):2894-916

30. Wang, X., Tabudravu, J., Rateb, M.E., Annand, K.J., Qin, Z., Jaspars, M., Deng, Z., Yu, Y.*, Deng, H*. Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus. Molecular Biosystems, 2013, 9(6):1286-9

31. Wu XM, Yu Y., Han LB, Li CL, Wang HY, Zhong NQ, Yao Y, Xia GX*.The tobacco BLADE-ON-PETIOLE2 gene mediates differentiation of the corolla abscission zone by controlling longitudinal cell expansion. Plant Physiology, 2012, 159(2):835-50

32. Zhang, Q.; Yu, Y.*, Thioether Crosslinkages Created by a Radical SAM Enzyme. ChemBioChem, 2012, 13(8), 1097-1099

33. Huang, S.; Zhao, Y.D.; Qin, Z.W.; Wang, X.L.; Onega, M.; Chen, L.; He, J.; Yu, Y.*; Deng, H.*, Identification and heterologous expression of the biosynthetic gene cluster for holomycin produced by Streptomyces clavuligerus. Process Biochemistry, 2011, 46, 811-16

34. Zhang, Q.; Li, Y.X.; Chen, D.D.; Yu, Y.; Duan, L.; Shen, B.; Liu, W. Radical-mediated enzymatic carbon chain fragmentation-recombination. Nature Chemical Biology, 2011, 7, 154-60

35. Yu, Y.; Guo, H.; Zhang, Q.; Duan, L.; Ding, Y.; Liao, R.J.; Lei, C.; Shen, B.; Liu, W. NosA Catalyzing Carboxyl-Terminal Amide Formation in Nosiheptide Maturation via an Enamine Dealkylation on the Serine-Extended Precursor Peptide. J AM CHEM SOC, 2010, 132(46), 16324-26.

36. Wang, J.; Yu, Y.; Tang, K.; Liu, W.; He, X.; Huang, X.; Deng, Z. Thiopeptide antibiotic cyclothiazomycin: Identification and Analysis of its biosynthetic gene cluster in Streptomyces hygroscopicus 10-22. (2010) Appl Environ Microb, 76(7), 2335-44.

37. Ding, Y.; Yu, Y.; Pan, H.; Guo, H.; Li, Y.; Liu, W. Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099. (2010) Molecular Biosystems, 6(7), 1180-85.

38. Yu, Y.; Duan, L.; Zhang, Q.; Liao, R. J.; Ding, Y.; Pan, H. X.; Wendt-Pienkowski, E.; Tang, G. L.; Shen, B.; Liu, W., Nosiheptide Biosynthesis Featuring a Unique Indole Side Ring Formation on the Characteristic Thiopeptide Framework. (2009) ACS Chem Biol, 4(10), 855-64.

39. Liao, R. J.; Duan, L.; Lei, C.; Pan, H. X.; Ding, Y.; Zhang, Q.; Chen, D. J.; Shen, B.; Yu, Y.*; Liu, W.* Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications. (2009) Chemisty & Biology, 16 (2), 141-47.

40. Liu, W.; Yu, Y. Combinatorial Biosynthesis of Pharmaceutical Natural Products. Biocatalysis for the Pharmaceutical Industry: Discovery, Development, and Manufacturing (Chapter 11) Wiley Press, ISBN: 978-0-470-82314-9, Oct. 2008, 229-246

41. Yu, Y.; Wang, H.Y.; Liu, L.N.; Chen, Z.L.; Xia, G.X. Functional identification of cytokinesis-related genes from tobacco BY-2 cells. (2007) Plant Cell Rep, 26(7), 889-94

42. Chen, Z.L.^#; Yu, Y.^#; Liu, L.N.; Xia, G.X. Isolation, characterization and functional analysis of a cdc48 homologue from tobacco BY-2 cells. (2007) Progress in Nature Science 17, 156-62. (^#Contributed equally)

43. Yu, Y.; Bai, L. Q.; Minagawa, K.; Jian, X. H.; Li, L.; Li, J. L.; Chen, S. Y.; Cao, E. H.; Mahmud, T.; Floss, H. G.; Zhou, X. F.; Deng, Z. X., Gene cluster responsible for validamycin biosynthesis in Streptomyces hygroscopicus subsp jinggangensis 5008. (2005) Appl Environ Microb, 71 (9), 5066-76.

44. Wang, H.Y. ^#; Yu, Y. ^#, Chen, Z.L.; Xia, G.X. Functional characterization of Gossypium hirsutum profilin 1 gene (GhPFN1) in tobacco suspension cells. Characterization of in vivo functions of a cotton profilin gene. (2005) Planta 222, 594-603. (^#Contributed equally)

45. 王岩；虞沂；赵群飞；孔毅；刘文，天然产物的生物合成和组合生物合成研究进展。国外医药（抗生素分册）2008，29（6），275-282

46. 张华；赵群飞；虞沂；陆大年；刘文，特异性克隆编码多肽合成酶还原结构域基因的PCR方法。中国抗生素杂志 2009，34（3），189-192

47. 吕美男；虞沂^*，2-脱氧链霉胺类抗生素的生物合成研究进展。中国科技论文在线, 2014

48. 张玉；虞沂^*，吡咯酰胺类化合物合成途径中醛基转移酶Pya26的功能研究。必威betway中文版学报（理学版），2016，62（1）：078-084

49. 黄胜；虞沂^*，二硫吡咯酮类抗生素的生物合成研究与代谢工程应用。微生物学报（微生物药物创新专刊），2016，3

专利

诺丝七肽的生物合成基因簇 (专利号：ZL 2009 1 0053427.7  授权公告日：2011年6月22日)

刘文；虞沂；段炼；雷春；丁莹；廖日晶