报告题目：Charm of dendrimer nanotechnology in biomedical applications
报 告 人：Prof. Ling Peng
报告时间：3月10日（星期五）上午10点
报告地点：医学部5号楼712室
个人简历：Dr. Ling Peng is currently a research director at the French National Scientific Research Center (CNRS) and a group leader at the Interdisciplinary Center of Nanoscience in Marseille (CINaM) in France. She carried out her undergraduate study in polymer science with Prof. Chen Rongshi at Nanjing University in China, her Ph.D program in organic chemistry with Prof. Albert Eschenmoser at the Swiss Federal Institute of Technology in Zurich, Switzerland, and her postdoctoral research in pharmaceutical science with Prof. Maurice Goeldner at the Louis Pasteur University of Strasbourg in France. She was recruited in CNRS in 1997, and promoted to CNRS research director in 2008 and to 1st class CNRS research director in 2015. She is working actively to develop multifunctional dendrimers as intelligent nanomaterials for drug and gene delivery, and molecular probes for exploring biological events and drug discovery.
Dr. Ling Peng has co-authored more than 100 scientific papers, 5 patents and 14 book chapters. One of the dendrimers developed by her team has been scheduled for clinical trials. Dr. Ling Peng has also coordinated and participated in different European projects. She is currently a member of the Editorial Advisory Board of Molecular Pharmaceutics, section editor of drug delivery for Current Medicinal Chemistry and Assistant Editor of New Journal of Chemistry.
报告摘要：The application of nanotechnology to engineer nanovectors for drug delivery is widely expected to bring breakthrough and create entirely novel therapeutics in biomedical applications, in particular, for cancer treatment.1 Dendrimers are ideal nanocarriers for drug delivery by virtue of their uniquely well-defined structure and multivalent cooperativity. We have recently established bio-inspired structurally flexible dendrimers and self-assembled supramolecular dendrimers as excellent nanocarriers for gene and drug delivery.2-5 In particular, self-assembling dendrimers are able to form modular and adaptive supramolecular nanostructures, which encapsulate drug molecules with high loading efficiency for effective delivery to combat drug resistance, offering new perspectives in molecular engineering of functional dendrimers in nanotechnology-based biomedical applications.
REFERENCES:
1. Blanco E, Shen H, Ferrari M, Nat. Biotechnol. 2015, 33, 941, Shi J, Kantoff PW, Wooster R, Farokhzad OC, Nat. Rev. Cancer 2017, 17, 20.
2. Wu et al, Chem. Comm. 2006, 351; Liu et al, Bioconjugate Chem. 2011, 22, 2461; Cui et al, Nat. Commun. 2016, 7, 10637.
3. Yu et al, Angew. Chem. Int. Ed. 2012, 51, 8478; Chen et al, Small 2016, 12, 3667; Hinman et al, ACS Appl. Mater. Interfaces, 2017, 9, 1029
4. Liu et al, Angew. Chem. Int. Ed., 2014, 53, 11822; Wei et al, Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 2978
5. Liu et al, Adv. Funct. Mater. 2016, 26, 8565.
