闵昶
职务/职称：教授、博士生导师
通讯地址：湖北省武汉市武昌区东湖路185号betway必威
教育与研究经历:
2022.8-至今 教授，betway必威
2019.9–2022.7 高级研究员, 药物研发, Incyte Cooperation
2016.11–2019.9 斯坦福大学，博士后
2011.9.–2016.10. 罗格斯（新泽西州立大学），博士
2009.9–2011.7 必威betway中文版，betway必威，硕士
2005.9–2009.7 必威betway中文版，betway必威，学士
研究方向:
药物化学，有机化学，抗癌小分子药物开发
1. 设计和开发新型抑制特定信号通路的抗癌药物小分子
2. 具有抗癌活性天然产物的合成，结构改造和构效关系研究
3. 开发快速建立抗癌活性小分子化合库的新方法
主要荣誉及奖励:
2015 Thomas Reid Fellow Award
2014 Van Dyke Research Award
2013 Krishnamurthy Award
2013 Poster Prize at the ACS Pharmaceutical Roundtable Green Chemistry Symposium
代表性论文（*共同第一作者）：
1. Barry M. Trost*（通讯作者）and Chang Min, “Total synthesis of terpenes via palladium-catalysed cyclization strategy.” Nat. Chem. 2020, 12, 568.
2. Frederick J. Seidl‡, Chang Min‡, Jovan A. Lopez and Noah Z. Burns. “Catalytic Regio- and Enantioselective Haloazidation of Allylic Alcohols.” J. Am. Chem. Soc. 2018, 140, 15646. (‡equal contribution)
3. Chang Min‡, Yingfu Lin‡ and Daniel Seidel, "Catalytic Enantioselective Synthesis of Mariline A and Related Isoindolinones via a Biomimetic Approach." Angew. Chem. Int. Ed. 2017, 56, 15353. (‡equal contribution)
4. Chang Min, Chih-Tsung Lin, and Daniel Seidel, “Catalytic Enantioselective Intramolecular Aza-Diels-Alder Reactions.” Angew. Chem. Int. Ed. 2015, 54, 6608–6612.
5. Chang Min‡, Nisha Mittal‡, Diana X. Sun and Daniel Seidel, “Conjugate-Base-Stabilized Brønsted Acids as Asymmetric Catalysts: Enantioselective Povarov Reactions with Secondary Aromatic Amines." Angew. Chem. Int. Ed. 2013, 52, 14084–14088. (‡equal contribution)
6. Chang Min and Daniel Seidel, “Asymmetric Brønsted Acid Catalysis with Chiral Carboxylic Acids.” Chem. Soc. Rev. 2017, 46, 5889−5902.
7. Chang Min and Daniel Seidel, “Stereochemically Rich Polycyclic Amines from the Kinetic Resolution of Indolines via Intramolecular Povarov Reactions.” Chem. Eur. J. 2016, 22, 10817−10820.
8. Chang Min, Abbas Sanchawala and Daniel Seidel, “Dual C–H Functionalization of N-Aryl Amines: Synthesis of Polycyclic Amines via an Oxidative Povarov Approach." Org. Lett. 2014, 16, 2756–2759.
9. Chang Min, Nisha Mittal, Chandra Kanta De and Daniel Seidel, “A Dual-Catalysis Approach to the Kinetic Resolution of 1,2-diaryl-1,2-diaminoethanes.” Chem. Commun. 2012, 48, 10853–10855.
10. Chang Min, Xin Han, Zongquan Liao, Xiangfei Wu, Hai-Bing Zhou and Chune Dong, “C3-Symmetrical Cinchonine-Squaramide as New Highly Efficient, and Recyclable Organocatalyst for Enantioselective Michael Addition.” Adv. Synth. Catal. 2011, 353, 2715–2720.
